Bioprotein Glycosylation Process in Poorly Controlled Diabetes: New Approach and Implications

REVIEW ARTICLE

Bioprotein Glycosylation Process in Poorly Controlled Diabetes: New Approach and Implications

Viroj Wiwanitkit

Affiliation: Wiwiwanitkit House, Bangkhae, Bangkok, Thailand


ABSTRACT

Diabetes mellitus is an endocrine disorder with a high prevalence rate, affecting millions of people worldwide. Based on the pathogenesis of diabetes mellitus, the problem is not solely due to a high blood glucose level, but also fluctuations in the blood glucose level. Those described processes strongly relate to the development of diabetic complications. In diabetic cases with poor glycemic control, an increased risk for complications can be expected. An important biochemical reaction that is observed in problematic cases with poor glycemic control is bioprotein glycosylation. Several proteins in humans can be glycosylated in the hyperglycemic state and become a problem that disturbs the health status of the patient. The bioprotein glycosylation process in poorly controlled diabetes is hereby focused. In this review, details of important glycosylated bioproteins are given. In addition, the modern concept of bioprotein glycosylation and further clinical implications are discussed.

Keywords: glucose, diabetes mellitus, bioprotein, glycosylation
Correspondence: Viroj Wiwanitkit, Wiwiwanitkit House, Bangkhae, Bangkok 10160, Thailand. Tel: +66 24132436; e-mail: wviroj@yahoo.com